Focus on diagnostics
We process the data
Cloud-based genetic diagnostics to accelerate laboratory workflows and enhance patient care.
The varvis® genomics platform is a complete solution for clinical diagnostics, supporting NGS raw data processing, genomics data management, and variant interpretation. Automated CNV and SNV analysis are clinically validated and completely integrated into the NGS workflow.
Automated. Validated. Fast.
varfeed® automates the processing of raw next-generation sequencing data from bcl, fastq or bam files. It performs all bioinformatics, including alignment and clinically validated CNV/SNV/Indel variant calling. All results are handed over to varvis® automatically. Pipeline validation is provided as a service – updates are included.
varvis® genomics software
Made for use in clinical diagnostics
varvis® is a clinical decision support system (CDS) and allows you to review, filter, and classify genetic variants. In addition, varvis® is your own comprehensive variant database. It supports the clinical decision-making process and is a registered CE-IVD device according to directive 98/79/EC.
Always up to date
allexes® provides the data for variant annotation to varvis®. allexes® does not only deliver the most recent versions of public databases, but also provides access to aggregated genomic reference data from all our users compliant with HIPAA and EU regulations.
Important quality metrics are monitored automatically for every single NGS sample, but also across batches over time. Don't waste a moment on manual QC.
Push the button
Convenient filtering options such as inheritance filters and virtual panels allow you to filter from thousands of detected SNVs and CNVs. Within seconds.
Our clinically validated CNV analysis provides significant time and cost savings compared to ligation based CNV detection methods.
No matter how many samples or how many sequencing runs you have: our fully automated process delivers results overnight. Guaranteed.
Identify rare and causative SNV and CNV in a single validated process and replace conventional PCR-based methods.
Do you need more than 15 minutes to interpret a whole exome? Accelerate WES interpretation by combining phenotype, family and inheritance information.
Detect somatic variants with validated high sensitivity using state-of-the-art molecular barcoding technologies.
Even the most complex scenarios are well covered in a single carrier screening filter in varvis® to solve your cases with just a few clicks.
University of Magdeburg
University of Leipzig
Synlab Zentrum für Humangenetik Mannheim
University of Göttingen
by Dr. Ben Liesfeld, January 25, 2023
There have been a lot of discussions about what IVDR Art 5(5) means for genetic diagnostic labs. In January 2023, the Medical Device Coordination Group issued a guideline that clarifies important items. This is our summary.
by Dr. Ben Liesfeld, August 19, 2022
Back in 2020 we were advertising hg38 as the better reference genome and highlighted potential challenges when transitioning from hg19 to hg38. More recently, the work of the T2T consortium revealed previously unknown shortcomings of hg38 which we will discuss here.
by Pragathi Prakash, April 8, 2022
When analysing large NGS assays usually dozens to hundreds copy number variants (CNVs) are expected. With integration of DGV, DECIPHER and the proprietary database allexes®, the varvis® software makes it easy to focus on the most significant variants.