NGS targeted panel analysis made ingeniously simple
The varvis® software empowers you to identify rare and causative CNVs, SNVs, and Indels in a single, performance-evaluated process, replacing conventional ligation-based screening with one comprehensive approach. Automate your NGS workflow and reduce turnaround time from hours to minutes.
A clinical decision support system – made for use in diagnostic procedures
Onboarding, IT and support services included
CNV analysis with proven performance for clinical diagnostics
Our automated and validated CNV analysis is fully integrated into the NGS workflow. Copy number variants are detected automatically alongside SNVs and Indels by our bioinformatics pipeline. Performance evaluation is offered as a service, ensuring you can trust the varvis® software as a reliable and effective tool for routine clinical diagnostics.
Trust your results
The quality of the CNV data demonstrates proven performance and meets all relevant standards for NGS performance evaluation.
Reduce your turn-around time
For most patients the result of the CNV analysis is immediately available without an additional confirmation.
One for all
Our CNV analysis is available for all genes and insensitive to SNPs.
Supreme expert support
Our team provides first-class support regarding workflow optimization, technical issues, training and documentation – even for the tricky cases. We are here to help!
Our CNV detection algorithm has demonstrated high performance across thousands of clinical samples. In this example, over 400 consecutive samples from routine diagnostics were analyzed using our bioinformatics CNV pipeline. The results were compared to gold-standard PCR-based methods, confirming accuracy for every individual probe and target region. The metrics represent typical results determined for performance evaluation.
100% sensitivity
All variants identified with PCR-based methods were also detected by our bioinformatics pipeline.
>99% specificity
Due to a very low false-positive rate, the varvis® CNV analysis is a very effective and reliable screening tool.
80% cost and time savings
Replace multiple expensive assays with a single comprehensive approach.
University of Magdeburg
A clincial decision support system
made for use in clinical diagnostics
The varvis® software is designed to deliver the optimum workflow for genetic testing labs and to make variant interpretation as reliable, fast and easy as possible. Cloud-native CE medical device software
Automate your NGS workflow
To really leverage all varvis® software features across your entire laboratory workflow, integration into your other software systems is key.
Build and utilize your own variant database
Systematically collect all variant data in a high-performance structured database and, at the same time, augment your data with high-quality data from all other users on our platform.
ACMG compliant classification
Interpret causative variants in concordance with the ACMG standards and store the evidence as part of your varvis® knowledgebase.
Features
Virtual panels
Quickly construct and easily manage virtual panels containing genes of interest and combine them with filters to focus on the variants that matter.
CNV Analysis with proven performance
Increase your diagnostic yield by utilizing our automated and reliable CNV analysis with proven performance.
Annotations
Review all relevant variant annotation at a glance
Coverage histogram
Receive immediate QC feedback about samples/regions failing quality thresholds such as low coverage regions to optimize your lab process.
Support and software as a service
Our dedicated expert service team offers first-class support for workflow optimization, technical assistance, training, and documentation, including performance test reports aligned with all relevant international guidelines.
No investment in IT
infrastructure
You initiate raw data upload by pushing a button. We deal with IT, processing and bioinformatics.
NGS performance tests – as a service
Just sequence the appropriate reference samples – we take care of the rest. Regular updates are included!
Cloud-native CE medical device software
Focus on diagnostics. We are certified so you can trust the software you are using.
Overnight express
No matter how many samples or how many sequencing runs you have: our fully automated process delivers results overnight. Guaranteed.
On-boarding made simple – we get you all set up within a week!
University of Magdeburg
University of Leipzig
Synlab Zentrum für Humangenetik Mannheim
University of Göttingen
Gemeinschaftspraxis für Humangenetik & Genetische Labore Hamburg
Get in touch and see for yourself
Read more
The varvis® API facilitates integration and automation of your workflows
by Ben Liesfeld, Jan 7, 2020
We design varvis to deliver the optimum workflow for genetic testing labs. To really leverage all varvis features across your entire laboratory workflow, integration into your other software systems is key.
The varvis® onboarding process
by Dr. Roberta Trunzo, April 16, 2024
Welcome to the varvis® software! We understand that, as a new customer, navigating through a new software platform can be overwhelming. That’s why we’ve created this comprehensive guide to get an overview of all the steps in the process. Our mission? To facilitate a smooth onboarding to our reliable and high-performance varvis® software and this step-by-step walk-through will ensure you make the most out of it.
varvis® Genotyping Service: sample identity check built-in
by Dr. Yvonne Kasmann, March 30, 2021
To comply with international quality standards, every laboratory is required to establish and perform sample identity checks to exclude a potential sample mix-up. Using an automated identity check, the varvis® Genotyping Service makes this as easy as possible.